What do we do?

We study the role of lipids in health and diseases by determining their interactions with lipid carrier proteins (albumin, HDL) and cognate G-protein coupled receptor (GPCR) by maximizing the preservation of their in vivo conditions. The research involves quantitative measurement of lipids interaction by the development of lipid binding assays in label-free, free solution arrangement, which we called Free Solution Assay (FSA) (shown below) and measurement of such FSA in real time using a cutting-edge technology, called Compensated Interferometric Reader (CIR) which was developed by Prof. Bornhop group at Vanderbilt University. The research at the interface of chemistry and biology adopts different strategies of cellular biology (cell culture,flow cytometry, electron microscopy, western blots), and biophysical/bioanalytical (Dynamic Light Scattering (DLS), Fluorescenece spectroscopy, microplate reader, chromatography techniques) approaches to investigate different lipids , and their interactions via four projects.